As far as strength of the trannies goes, there is a lot of speculation but you really dont see anyone breaking them from pure hp.
The newer generation transmissions are pretty stout. There are finally some TD guys in the 10's on manual transmissions so there is some abuse finally happening.
Im hoping some people here start breaking tranny parts (and if things hold together then yay)
Some reading I did recently leads me to believe the small spline a543 has less beefy gears then the large spline 3.77 trannies (I dont know if the large spline 3.50 tranny has the older gears or the newer ones).
Then some personal blathering.
My race car has a small spline 3.50 a543 in it that is definitly "worn" (decent synchro but horrible reverse idler gear rattle that Im ntot sure is the only problem, there is also a LOT of play in the gears) but I have 2 spare 3.77 trannies (not sure how nice they are). My spirits 3.77 is definitly in need of a rebuilt with no 5th gear synchro left and reverser idler gear rattle and annoying play between the engine and the wheels that shakes the car on decel. Car drives well enough and i can rev match + double clutch to get into 5th gear so I will not be rebuilding anytime soon :P Just makes the car almost impossible for other people to drive.
I have never used a rebuilt/newish 5 speed tranny. Both of the transmissions I have actually used are pretty sloppy (play in the gears, snaping feeling if you dont ease into the gas) and on decel will shake the car at certain rpms